http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9707834-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f34119b232d292c72e632b62008eca90 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-921 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L33-0029 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-00 |
| filingDate | 1996-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_504a7b3e0fe2f6c13f10728f49d3535b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9fcca2e9eb2e5161f5655cad00c7519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1c7abd65e4e91ad67daf92165e55e8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60cc3fc351045d6ed32a601f2a345154 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8965980a88872b1c5b1464b89140b13e |
| publicationDate | 1997-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9707834-A3 |
| titleOfInvention | Method for making heparinized biomaterials |
| abstract | An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH in the range of about 4.5-8. This mixture is reacted for at least 3 hours while protected from light and is then applied to the immobilized amine groups. This is an improvement over the prior art methods which included using an excess of periodate and then stopping the reaction at a desired point by the addition of glycerol since the conversion of only a few of the natural functional groups to aldehydes better preserves the antithrombotic bioeffectiveness of the heparin molecules bound to the surface. The invention also avoids the prior art steps of drying and reconstituting the heparin by providing a reacted mixture of heparin and periodate that can be stored as a stable liquid and applied directly to the aminated surface several days later. |
| priorityDate | 1995-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.