| abstract |
Therapeutic uses of liposomes and a lipoprotein particle composition are disclosed. In addition, a lipoprotein particle and a therapeutic lipoprotein particle composition are disclosed. A suspension of small, unilamellar vesicles, composed essentially of lecithin phospholipids with low phase transition temperatures, may be used to treat disease conditions associated with an elevated serum Lp(a) concentration. Treatment continues until a significant drop in serum Lp(a) concentration is observed. A lipoprotein particle, consisting essentially of lecithin phospholipids with low phase transition temperatures and human apoproteins A and C, is also disclosed, as is a therapeutic composition comprising the lipoprotein particles. This composition is also useful in treating disease conditions associated with elevated serum Lp(a) levels, as well as in treating hypertension and acute renal failure. |