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filingDate 1996-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1997-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9706263-A1
titleOfInvention Hybrid protein comprising t-helper cell stimulating epitopes and b-cell epitopes from the major outer membrane protein of chlamydia trachomatis and its use as a vaccine
abstract A recombinant hybrid protein is disclosed which expresses at least one chlamydial B-cell neutralizing antibody stimulating epitope and one chlamydial T-helper cell epitope, and is capable of inducing antibodies immunoreactive with Chlamydia trachomatis in vertebrate. Also disclosed is a nucleic acid molecule comprising at least a portion encoding the recombinant hybrid protein and an antibody immunoreactive with C. trachomatis producible by immunizing a host with an immunogenic component comprising the recombinant hybrid protein or the nucleic acid molecule and a carrier. The present invention relates to recombinant hybrid proteins, containing both B and T-helper cell epitopes which can be used in vaccines to provide a protective response to C. trachomatis serovars.
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