| abstract |
The present invention provides compounds of formula (I), wherein R1 is a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, oxygen and sulphur, which group is optionally substituted; R2 is hydrogen, halogen, C¿1-6?alkyl, C1-6alkoxy, CF3, OCF3, NO2, CN, SR?a, SORa, SO¿2Ra, CO2R?a, CONRaRb, C¿2-6alkenyl, C2-6alkynyl or C1-4alkyl substitued by C1-4alkoxy, where R?a and Rb¿ each independently represent hydrogen or C¿1-4?alkyl; R?3¿ is hydrogen, halogen, C¿1-6?alkyl, C1-6alkoxy substituted by C1-4alkoxy or CF3; R?4, R5, R6, R9a, R9b¿, A, X and Y are as defined in the specification; and m is zero or 1, and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. |