| abstract |
A ketonitrile derivative represented by general formula (1) or a salt thereof and an antibacterial agent and a drug containing the same, wherein R1 represents hydrogen or lower alkyl; R?2, R3, R4 and R5¿ are the same or different and each represents hydrogen, halogeno, nitro, lower alkyl, lower alkoxy or optionally substituted phenoxy; X represents an optionally substituted aromatic hydrocarbon group or an optionally substituted heterocyclic group; and Y represents an optionally substituted aromatic hydrocarbon group, an optionally substituted heterocyclic group, carbonyl substituted by an optionally substituted aromatic hydrocarbon group, carbonyl substituted by an optionally substituted aromatic heterocyclic group, N,N-disubstituted carbamoyl or heterocycle-substituted alkyl. The compound is excellent in antibacterial activity on Gram-positive and Gram-negative bacteria. |