| abstract |
Thrombin-induced and ADP-induced platelet and other cell activation is inhibited without affecting thrombin's other proteolytic activity by administration of a bradykinin sequence related analogous peptide. Bradykinin analogs are peptides to which substitutions, additions or deletions have been made to the first four amino acids of the amino acid sequence of native bradykinin. The bradykinin analogs described inhibit α-thrombin-induced and ADP-induced platelet activation and secretion, inhibit α-thrombin-induced calcium mobilization, and prevent α-thrombin from cleaving its platelet receptor. The bradykinin analogs may comprise single- or multiple-chain peptides. |