| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd30bbbca4f24925a41e29e94e00f030 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-27
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate |
1996-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7974c259948e64cd13ffc1e7c4bca23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2dbc5de7aeee3550865d976737fe22cf |
| publicationDate |
1996-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9640771-A1 |
| titleOfInvention |
SINGLE CHAIN ANALOGS OF THE TGF-β SUPERFAMILY (MORPHONS) |
| abstract |
Disclosed is a family of single-chain polypeptide constructs designed to agonize or mimic members of the TGF-β superfamily by binding to a cell surface receptor complementary to the superfamily member. The single-chain constructs of the invention called 'morphons' contain in a single biologically active subunit interacting finger and heel regions which together define a tertiary protein structure complementary to the ligand binding surface of a receptor that binds a TGF-β superfamily member. Also disclosed are truncated versions of the morphon constructs. Methods are disclosed for making and using single-chain morphons that have binding affinity for predetermined receptors of the TGF-β superfamily. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8084664-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11578110-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109311957-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8138148-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9921574-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0824545-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2377876-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005518788-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7754689-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9921574-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02072759-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8163974-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7763769-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7125679-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9818816-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8735644-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007143161-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0824545-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02072759-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7700819-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017032853-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007143161-A3 |
| priorityDate |
1995-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |