| abstract |
The present invention is directed to non-peptidic factor Xa inhibitors which are useful for the treatment of arterial and venous thrombotic occlusive disorders, inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors provide compounds of structure (I), wherein each R1 is independently one of alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl; each R?2 and R3¿ is independently one of hydrogen, alkyl, aryl or arylalkyl; Y is a bond, or is one of -(CH¿2?)p-, cycloalkyl, aryl or C2-10 heterocycle; and m, n and p are each independently 1 to 10. |