| abstract |
Disclosed are novel classes of antiandrogenic compounds including saturated and unsaturated fatty acids, catechin gallates, their derivatives, and synthetic analogs, and their use in treating disorders associated with androgenic activities. Also disclosed is the use of compositions not previously known for their antiandrogenic activity in treating disorders related to androgenic activities and cancers. Methods are disclosed for the treatment of breast cancer, prostate cancer, and other tumors using compositions comprising testosterone compositions in combination with 5α-reductase inhibitors such as fatty acids and catechin compositions. Compositions and methods are also disclosed for use in reducing lipid production in an animal, reducing organ and body weight, treating hair loss, benign prostatic hyperplasia, reducing sebum production, and other related disorders. |