| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76c1b382ef9bdeaabeb622fd3e7d2a43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c59e092645365abed28fb2c9ad63170
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_600db5b93a54999d3db277d10725d525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4706
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 |
| filingDate |
1996-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d27656853d4eb9eef92534c102a0a59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac4c5d0c27984d7676ad78a07e48f4df |
| publicationDate |
1996-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9634604-A1 |
| titleOfInvention |
Inhibition of intracellular acidification |
| abstract |
Methods of attenuating acidification in a eukaryotic cell are provided as a means of inhibiting apoptosis (programmed cell death) in a cell. Alkalinizing agents useful in the methods are disclosed and include organic bases as well as blockers of ion channels which participate in the homeostasis of intracellular pH. Diseases associated with apoptosis and which are treatable by the methods of the invention include reperfusion injury following myocardial infarction, gastrointestinal epithelial cell damage following chemo- or radiation therapy, as well as many other diseases. Methods are also provided for in vitro methods screening to identify candidate alkalinizing agents. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10928405-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11116737-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012045451-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0247672-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8911711-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9709556-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9063127-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9845242-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0247672-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010078020-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009138156-A1 |
| priorityDate |
1995-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |