| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a2b2980777956279eeb733649b518c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3d068297d74aa2291f34a314f3a33ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d87cfb36461fd0109a9d10d64fe7416e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcc25227503b1344cf5e1c3f516419f7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate |
1996-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_971724191c58faa8306d6cb06d606dba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b550c4691820628548f52eb724fc85f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_033e6eb879e710f556f2b07c315de861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f410a5b4af9c1eb8c4aa7c7b99fc926 |
| publicationDate |
1996-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9633982-A1 |
| titleOfInvention |
Piperazinones useful as inhibitors of platelet aggregation |
| abstract |
The present invention provides compounds and medicines effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell-adhesion. Especially, the compounds of this invention perform platelet aggregation action without remarkable elongation of hemorrhagic period and can be used as a safe and long-acting antithrombotic drug as compared with known substances showing the same activity. Compounds of this invention are piperazinones of formula (I) wherein A?1 and A2¿ independently are a proton-accepting group or a group convertible into the proton-accepting group; D is a spacer having a 2 to 6 atomic chain optionally bonded through a hetero-atom and/or a 5- or 6-membered ring (provided that the 5- or 6-membered ring is, depending on its bonding position, counted as 2- or 3-atomic chains); R1 is hydrogen atom or a hydrocarbon group; R2 is hydrogen atom or a residual group formed by removing -CH(NH¿2?)COOH from an alpha-amino acid, or R?1 and R2¿ may be combined to form a 5- or 6-membered ring; P is a spacer having a 1- to 10- atomic chain optionally bonded through a hetero-atom and/or a 5- or 6-membered ring (provided that the 5- or 6-membered ring is, depending on its bonding position, counted as 2- or 3-atomic chains); Y is an optionally esterified or amidated carboxyl group; and n is a number ranging 0 to 8, and salts thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6680312-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6242600-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9952861-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6117455-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9940075-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6403595-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6359134-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6322550-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5888531-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0950658-A1 |
| priorityDate |
1995-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |