| abstract |
1-[φ-(3,4-Dihydro-2-naphthalenyl)alkyl] cyclic amine derivatives represented by general formula (I) and salts and N-oxide derivatives thereof, wherein R?1 and R2¿ represent each hydrogen, halogeno, hydroxy, alkyl, alkoxy, hydroxymethyl, etc., or R?1 and R2¿ form together methylenedioxy, trimethylene, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, hydroxy, alkyl, etc.; R5 represents hydrogen, alkyl, etc.; p is an integer of from 2 to 6; and q is an integer of from 3 to 7; excluding the case where R?1, R2, R3, R4 and R5¿ are all hydrogen, p is 2 and q is 5. The compounds have a potent effect of suppressing urinary reflex and thus are useful as a remedy for frequent urination and urinary incontinence. |