| abstract |
Use of a compound comprising one or more α-amino acid residues of general formula (I), wherein R is selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, C1-C20 alkenyl, aryl and aralkyl groups and a group R5-OCO- where R5 is selected from C¿1?-C20, C1-C20 alkenyl, aryl and aralkyl groups; R?1 and R2¿ are independently selected from the group consisting of hydrogen and optionally substituted C¿1?-C6 alkyl, C1-C6 alkenyl, C7-C12 arylalkyl and aryl groups; or R?1 and R2¿ together represent a group =CR6R7, wherein R?6 and R7¿ are independently selected from hydrogen, halogen, and optionally substituted C¿1?-C6 alkyl and aryl groups; wherein the compound does not contain free thiol groups; or a pharmaceutically acceptable salt thereof in the preparation of a medicament suitable for the treatment of a disease state caused by production of free radical species or in which free radical species are produced is provided, together with formulations and methods for their preparation. |