| abstract |
This invention encompasses an isolated DNA encoding all or a portion thereof of a novel member, ELF-2, of a family of ligands of the Eph receptor tyrosine kinases, along with the isolated polypeptides expressed by the DNA. The invention further encompasses DNA encoding forms of the ELF-2 ligand and polypeptides corresponding thereto. The ELF-2 ligand is important in cellular communication during pattern formation in embryos and can be used to alter neurological development, oncogenesis, and growth regulation. |