http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9625431-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5ddced4c203e56346f054e364b141ba |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate | 1995-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15368fe48fb61b9738868de8c162b17b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f04d4a1fa58a91e4053d952070bc2c3b |
| publicationDate | 1996-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9625431-A1 |
| titleOfInvention | Cancer-associated mar binding protein |
| abstract | The present invention provides a substantially purified protein, p114-MBP, which has an apparent molecular mass of about 114 kDa and specifically associates with a matrix attachment region DNA sequence context (MAR). p 114-MBP is characterized, in part, by having substantial MAR binding activity in malignant tumor tissue but not in a corresponding non-cancerous tissue. The invention also provides a method of detecting the presence of malignant tumor tissue in a cell sample suspected of containing malignant tumor tissue by contacting the sample with a MAR, under conditions that allow the specific association of the MAR with p114-MBP, and detecting such specific association, which indicates the presence of malignant tumor tissue in the cell sample. The present invention further provides a method of diagnosing cancer in a subject suspected of having cancer by contacting a cell sample obtained from a subject with a MAR under conditions that allow the specific association of the MAR with p114-MBP and detecting such specific association, which indicates that malignant tumor tissue was present in the sample and, therefore, is diagnostic of cancer in the subject. The invention also provides a method of determining the prognosis of a cancer patient. |
| priorityDate | 1995-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.