| abstract |
Novel benzoic acid derivatives have formula (I) wherein: -X- represents C1 to C6 alkylene, C2 to C6 alkenylene or a divalent moiety having the structure -(CH2)m-Z- in which m is an integer from 0 to 3 and Z represents -O-, -S- or -NH-; -Y- represents a direct bond, C1 to C6 alkylene, C2 to C6 alkenylene or a divalent moiety having the structure -(CH2)m-Z-(CH2)n in which m and n are each, independently, an integer from 0 to 3 and -Z- represents -O-, -S- or -NH-; R represents a 5- or 6-membered carbocyclic or heterocyclic ring or a carbocyclic or heterocyclic fused ring system containing up to 10 members in the ring, which carbocyclic, heterocyclic or fused ring system may be saturated or unsaturated and may contain up to two substituents selected from lower alkyl, methoxy, halo and trifluoromethyl; and R?1 and R2¿ are each, independently, selected from hydrogen, lower alkyl, methoxy, halo and trifluoromethyl. The benzoic acid derivates are useful as anti-inflammatory agents. |