abstract |
Combinations of an ACE inhibitor, an aldosterone receptor antagonist and a diuretic, i.e., 'triple therapy' combinations, are described for use in treatment of circulatory disorders. Of particular interest are triple therapies using captopril or enalapril co-administered with a low-dose of spironolactone and furosemide. This triple therapy would be particularly useful to treat or prevent the progression of congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia. |