| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa8eb09b22efa456b36e56ad9a73fd69 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-915
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-738
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-801 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 |
| filingDate |
1996-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddccb706b31f37415631fa5ad5237558 |
| publicationDate |
1996-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9624340-A1 |
| titleOfInvention |
A method of preparing stable drug nanoparticles |
| abstract |
Stable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier absorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by providing a drug substance, depyrogenating grinding media, mixing the drug substance, grinding media and autoclavin and adding a surface modifier either during autoclaving or after autoclaving and subsequently wet milling. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7780989-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100904931-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067032-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8309133-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722091-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7473693-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6835396-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9700866-B2 |
| priorityDate |
1995-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |