| abstract |
A method of selecting anti-aggregation molecules with chaperone-like activity that have characteristics including binding to a native target molecule epitope with a high binding constant and which are non-inhibitory to the biological activity of the target molecule when bound. The method includes the steps of mixing a denatured target molecule with a presumptive anti-aggregation molecule and then determining if the target molecules are prevented from self- or induced-aggregation. The nonaggregated target molecule coupled to the anti-aggregation molecule is then tested for bioactivity. |