| abstract |
An antisense nucleic acid homolog having at least one nucleoside represented by general formula (1) in the same chain of a nucleic acid homolog having been modified or replaced at DNA, RNA or a phosphoric acid diester bond, wherein B represents adenin-9-yl, guanin-9-yl, hypoxanthin-9-yl, thymin-1-yl, uracil-1-yl or cytosin-1-yl; and X and Y are the same or different and each represents hydrogen, hydroxy, halogeno or lower alkoxy. Examples of the modified phosphoric acid diester bond of this antisense nucleic acid derivative include phosphorothioate, alkylphosphorothiate, N-alkylphosphoamidate, phosphorodithioate and alkylphosphonate bonds. Thus it is possible to provide an antisense molecular drug having a low toxicity and suppressing infection with herpesvirus, influenza virus, human immunodeficiency virus, etc., or the action of oncogenes. |