| abstract |
This invention provides processes for producing phthalide compounds which comprise cultivating Phanerochaete velutina FERM BP-4787, and then isolating phthalide compounds from the fermentation broth. The compounds produced by these processes include compounds of formula (I), wherein R is a group of formula (II), (III), -(CH2)3-C(=O)-(CH2)2-C(=O)-CH3, -(CH2)5-C(=O)-(CH2)2-C(=O)-CH3, -(CH2)6-CH(OH)-CH3 or -(CH2)6-C(=O)-CH3. The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of diseases, disorders and adverse conditions caused by Helicobacter pylori and is particularly useful in the treatment of gastroduodenal disorders, diseases and adverse conditions cause thereby. |