| abstract |
Therapeutically active, heteroaryl-substituted deoxy glycero-phosphoethanolamines are disclosed having general formula (I) wherein one of X, Y or Z is a fatty ether substituent, one is a heteroaryl ring substituent with 1 - 4 nitrogens as the only heteroatoms, one of which is bonded to a carbon of the glyceryl backbone, and one is a phosphoethanolamine substituent substituted at the nitrogen, provided that each of X, Y and Z is a different substituent. Also disclosed are intermediates in processes for making compounds of formula (I). The intermediates are represented by a modification of general formula (I) in which the phosphoethanolamine substituent is replaced with an hydroxyl group. The invention encompasses all optical isomers and stereoisomers of the compounds of formula (I) and the intermediates and salts of these compounds, including the isomers. The therapeutically active compounds of the invention have anti-tumor, anti-psoriatic and anti-inflammatory activities. The invention entails pharmaceutical compositions comprising the therapeutically active compounds and methods of using the therapeutically active compounds to treat cancerous tumors, psoriasis and inflammation. |