| abstract |
A lyophilized preparation of a reversibly thermogelling water-base composition comprising an effective dose of a medicine, 0.2 - 2.1 % (w/v) of methylcellulose (containing 26 - 33 % of methoxyl groups), 1.2 - 2.3 % (w/v) of citric acid, and 0.5 - 13 % (w/v) of polyethylene glycol. This preparation serves to keep a moisture-sensitive medicine stable till the time of its use and can be converted into a composition which reversibly gels upon heating when applied to the affected part by adding a suitable amount of a solvent. |