| abstract |
This invention is a method for the treatment of macular degeneration, and in particular, age-related macular degeneration. The method entails application of an effective amount of Transforming Grtowth Factor-β (TGF-β) to the area of the retina requiring treatment. In one treatment regime, the TGF-β is applied locally over the area of the macula following vitrectomy of the eye. In a second treatment regime, a portion of the total TGF-β dose is injected into the subretinal space and the remainder of the dose is applied locally over the area of the macula. This second treatment regime is also performed during or following vitrectomy of the eye. Alternative routes of administration of TGF-β include intrascleral and suprachoroidal administration. |