http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9609314-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_753753b9c2bd482eebbae2e499505dc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d3e9d77ff72f5282325b4e142dfa5b4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8885a09d31b8ad044cdb4396d90c8c18 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 1995-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99f9305f4b491341ae0c1b8c39e50418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ce3b0bc2a713f14f5448e06f6705ce8 |
| publicationDate | 1996-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9609314-A3 |
| titleOfInvention | Method for loading solid supports for nucleic acid synthesis |
| abstract | New methods of loading solid supports for oligonucleotide synthesis are presented. The new methods comprise coupling a succinylated nucleoside to a solid support using diisopropylcarbodiimide (DIC) as an activator and N-hydroxybenzotriazole (HOBT) as an acid catalyst. DIC is substantially cheaper than the currently used activating agent, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (DEC). Furthermore, in the preferred embodiment, when it is used in combination with HOBT, coupling is more efficient, requiring less nucleoside to achieve the same loading densities as in the prior art. The loading process is faster than prior art methods and the overall cost savings of about 43 % are realized. |
| priorityDate | 1994-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.