abstract |
The present invention relates to compounds of formula (I) wherein: R?1, R2, R3, R4 and R5¿ are selected from a variety of suitable aromatic substituents; R6 is hydrogen, C¿1-6?alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenyl, or C2-4alkyl substituted by C1-4alkoxy or hydroxy; R?7¿ is hydrogen, C¿1-6?alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenyl, C2-4alkyl substituted by C1-4alkoxy or hydroxy, or the group C(=NR?c)NRaRb; or R6 and R7¿, together with the nitrogen atom to which they are attached, form an optionally substituted saturated heterocyclic ring of 4 to 7 ring atoms which may optionally contain in the ring one oxygen or sulphur atom or a group selected from NR8, S(O) or S(O)¿2?; or R?6 and R7¿, together with the nitrogen atom to which they are attached, form a piperidino ring substituted by a spiro-fused indene or indoline group, each of which may be unsubstituted or substituted; R8 is hydrogen, C¿1-4?alkyl, hydroxyC1-4alkyl or C1-4alkoxyC1-4alkyl; R?9a and R9b¿ are each independently hydrogen or C¿1-4?alkyl, or R?9a and R9b¿ are joined so, together with the carbon atoms to which they are attached, there is formed a C¿5-7? ring; X is selected from -CH2CH2-, -COCH2- or -CH2CO-; and Y is hydrogen, or C1-4alkyl optionally substituted by a hydroxyl group; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. |