| abstract |
A compound of formula (I) and its pharmaceutically acceptable salt, wherein R is hydrogen or hydroxy; Ar is unsubstituted or substituted phenyl; X is unsubstituted or substituted phenyl or heterocyclic, mono-, di- or tri-halomethyl, cyano, or the like; and X1 is phenyl, furyl, thienyl, pyridyl, thiazolyl, benzofuryl, benzothienyl or the like. These compounds have agonist activity toward opiod kappa receptor and are thus useful as analgesic, antiinflammatory, diuretic, and neuroprotective agent. |