http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9604379-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cbff64022f95c237c0bd3ec8656ca |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-18 |
| filingDate | 1995-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d234b38c0db2e92496c96de34e4c3c9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b7576b55ec91d7b12472c125168d631 |
| publicationDate | 1996-02-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9604379-A1 |
| titleOfInvention | Methods and compositions for the expression of a bone and prostate derived growth factor |
| abstract | The role of tumor cell-host stromal interaction and stromal-specific growth factors in prostate cancer growth, progression and metastasis to the axial skeleton were investigated. A bone and prostate-derived growth factor (BPGF-1) was identified and cloned from an expression cDNA library prepared from human bone stromal cells. The cloned BPGF-1 cDNA comprised 3171 nucleotides with a single open reading frame of 1620 nucleotides. The BPGF-1 encodes two transcripts (3.3 and 2.5 kb) with approximately equal intensity. Polyclonal antibodies generated from the synthetic peptides that correspond to the nucleotide sequences of the cloned BPGF-1 cDNA reacted with a single putative BPGF-1 protein with an apparent molecular weight of 70 kDa. Southern blot analysis of human genomic DNA revealed that there is a single copy of BPGF-1 gene of 15 kb in size within BamHI sites. The cDNA for BPGF-1 encodes a protein that stimulates the proliferation of prostatic epithelial cells. The BPGF-1 gene is expressed predominantly in bone, prostate and seminal vesicles, with substantially higher expression in the bone than that of the prostate and seminal vesicles. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5914251-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6025204-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6075008-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6197939-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9817798-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9856917-A1 |
| priorityDate | 1994-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.