| abstract |
Compounds of formula (I) wherein Z represents a methylene group, a methine group, a group of formula ⊃NH or a group of formula ⊃N-, and W represents a methylene group, a methine group, a sulfur atom or a group of formula νS→(O)v, where v is 1 or 2; ... is a single or double bond; at least one of Y?1, Y2, Y3 and Y4¿ represents a carboxyl group, a sulfonamide group or a group of formula -(A)¿p-B?1-T1, wherein A is S or O, T1 is a carboxyl group, a thiocarboxy group, a dithiocarboxy group, a sulfonamide group or a tetrazolyl group, B1 is a bond, an optionally substituted alkylene group and p is 0 or 1; the rest of Y?1, Y2, Y3 and Y4¿ are the same or different and are H, halogen, nitro, OH, SH, NH¿2?, optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aryl, aralkyloxy, aralkylthio and Y?1 + Y2¿ may together be a lactone or keto; one of R?1 and R2¿ is H, alkyl, alkanoyl, aryl, arylcarbonyl, aralkyl, carboxyl, sulfonamide or a group of formula -(O)¿q-B?2-T2, wherein T2 is COOH, sulfonamide or tetrazolyl, B2 is an optionally substituted alkylene, and q is 0 or 1; the other of R?1 and R2¿ is H, alkyl, aryl or aralkyl, or R?1 and R2¿ together represent a group of formula (Ib'), wherein [R?10, R11 and R12¿ are the same or different and each is H, OH, halogen, haloalkyl, optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl or alkylsulfonyl]; R3 is H or an amino protecting group; and pharmaceutically acceptable salts and esters thereof are allosteric effectors at muscarinic receptors, and are useful in the treatment and prophylaxis of disorders associated with muscarinic receptors. |