| abstract |
Latent growth factors such as TGFβ in tissue culture or healing wounds are converted to active form by matrix vesicle extract or through the medium of matrix vesicles stimulated with Regulator of Enhancing Factor (REF). REFs include 1,25-dehydroxy vitamin D and steroid hormones. Matrix vesicles having REF intercalated into the vesicle membrane are provided. Polymeric implant and cell culture scaffolding materials with matrix vesicles, matrix vesicle extract, REF or latent growth factor are also provided. |