Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5f70671e048ee77f732fee1193ca734 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30762 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-2817 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2230-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B17-00491 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2310-00365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2240-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30971 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2002-30764 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-3094 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3895 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0655 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3817 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3633 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3852 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-30756 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3654 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-28 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-30 |
filingDate |
1995-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e669ccaccba583dbeabb5dbe8914ed94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22d128fa374cf94463c394a029b951a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac9d67dbb5a4e62e8ff9df028722d218 |
publicationDate |
1995-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-9530742-A1 |
titleOfInvention |
Methods and compositions for the repair of articular cartilage defects in mammals |
abstract |
Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extracellular matrix components, type II colagen and sulfated proteoglycans. The proliferated cells then are seeded into a pre-shaped well having a cell contacting, cell abhesive surface. The cells cultured in the well redifferentiate and begin to secrete cartilage-specific extracellular matrix again. Accordingly, essentially unlimited amounts of synthetic cartilage may be prepared from small samples of biopsy tissue. Also provided are methods for surgically repairing articular cartilage defects in mammals using the synthetic cartilage prepared in accordance with the invention. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0812351-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0812351-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005012512-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6365405-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19540487-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1181908-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1384452-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1061812-C http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9694107-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0119964-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0119965-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1459709-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2798671-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2801317-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1360948-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9947186-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1085082-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1085084-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CH-703968-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007083504-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9370606-B2 |
priorityDate |
1994-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |