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filingDate 1995-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec96f6af4dbd1719f35cdf344eba0a61
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publicationDate 1995-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9530648-A1
titleOfInvention Process for producing isomer mixtures from o-phenoxyalkylhydroxyl amines or o-phenoxyalkyloximes
abstract A process is disclosed for producing isomer mixtures from O-phenoxyalkylhydroxyl amines Ia: H2N-O-CH2-CH(R1)-O-Ar and Ib: H¿2?N-O-CH(R?1)-CH¿2-O-Ar (wherein R1 represents alkyl, Ar where appropriate a substituted phenyl) and the corresponding salt mixtures. This process involves the following steps: (a) an isomer mixture of O-(2-hydroxyethyl)-oximes (IIa) and (IIb) (in which R2 is an alkyl and R3 is an alkyl or alkoxy, or R?2 and R3¿ together with the common C atom form a 5-7 member ring) is converted by reaction with a sulphonyl halogenide of formula (III): Hal-SO¿2-R?4 (wherein R4 represents an organic group and Hal is a halogen) in the presence of a base to form the corresponding sulphonate mixture of (IVa) and (IVb); (b) this sulphonate mixture is reacted in the presence of a base with a phenol of formula (V): HO-Ar to produce a mixture of O-phenoxyalkyloximes of general formulae (VIa) and (VIb); (c) the mixture is hydrolysed in the presence of an acid and, if required, (d) the O-phenoxyalkylhydroxyl amines (Ia) and (Ib) are released from the resulting salts using a mineral base. The O-phenoxyalkylhydroxyl amines (Ia/Ib) and their precursors (VIa/VIb) are important intermediate products for plant protective agents and drugs.
priorityDate 1994-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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