| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a92df8725b9446d653f14df369cef18 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L24-043 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L24-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L26-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L24-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L24-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate |
1994-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05e000399815ccfb88d05a29d3a52cc1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75362ca433272552e6fff7a629b306bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40575b39a87b9a9fb40c22f25f084001 |
| publicationDate |
1995-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9523167-A1 |
| titleOfInvention |
Process for the obtention of a biological adhesive comprising fibrinogen, factor xiii and fibronectin |
| abstract |
The present invention relates to a process of making a concentrate of coagulation proteins starting with whole human or animal plasma. This concentrate is used as a biological adhesive when extemporaneously mixed to thrombin. The concentrated proteins include mostly fibrinogen, fibrin stabilizing factor (factor XIII) and fibronectin. The claimed process has the advantage of being short of execution while providing an excellent yield of coagulable proteins. No protease inhibitor has to be added during the process. The process involves steps of separation by 'salting-out' in presence of amino-6 hexanoic acid which prevents co-precipitation of plasminogen with the desired coagulable proteins. The proteins so obtained are very stable after reconstitution in water for at least 24 hours at room or body temperature. After mixing with thrombin and calcium, the adhesive shows excellent strength and biocompatibility. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6579537-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007131638-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7816495-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0047621-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7241603-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4771594-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-774118-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002539087-A |
| priorityDate |
1993-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |