| abstract |
The invention provides a method of identifying a compound having the ability to block the low-affinity gastrin-cholecystokinin type C receptor, comprising the step of measuring the ability of said compound to block the binding to gastrin-binding protein of a compound selected from the group consisting of a gastrin-related peptide, a cholecystokinin-related peptide, an antagonist of gastrin or of cholecystokinin, an acyl CoA, an enoyl CoA, an antibody to gastrin, and an antibody to cholecystokinin. Several ways in which the method of the invention can be carried out are described. Thus, the invention provides a general screening method for identifying antagonists of the gastrin-binding protein interaction, which are useful for treatment of diseases involving rapidly proliferating cells, and for controlling gastric acid secretion. Compositions and methods of treatment are also claimed. |