| abstract |
There is disclosed a compound, pharmaceutical composition and methods for increasing mesenchymal cell migration including smooth muscle cells and endothelial cells and for peripheral nerve regeneration. This will promote tensile strength and rapid vascularization of wounds while accelerating the healing process. The inventive pharmaceutical compositions act as a platelet derived growth factor (PDGF), fibroblast derived growth factor (FGF), epidermal derived growth factor (EGF), vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) agonist, comprising an effective amount of a phosphatidic acid (PA) or bis PA species, or combination thereof. The pharmaceutical composition is useful for the treatment of wound healing or surgical healing of skin, vasculature, soft tissue or bone due to physical trauma, surgical procedures, fractures of bone or spinal cord, burns or soft tissue injury. The pharmaceutical composition is also useful for the treatment of tissue regeneration in areas of devascularized tissue or organ trauma, including central nervous system tissue and peripheral nervous tissue. |