| abstract |
The present invention relates to nucleotide sequences of deltex genes, and amino acid sequences of the encoded deltex proteins. The invention further relates to fragments and other derivatives, and analogs, of deltex proteins, as well as antibodies thereto. Nucleic acids encoding such fragments or derivatives are also within the scope of the invention. Production of the foregoing proteins and derivatives, e.g., by recombinant methods, is provided. In a specific embodiment, the invention relates to Drosophila deltex nucleic acids and proteins. In another embodiment, the invention relates to human deltex nucleic acids and proteins. In specific embodiments, the invention relates to deltex protein derivatives and analogs of the invention which are functionally active, or which comprise one or more domains of a deltex protein, including but not limited to the Glu-rich clusters, SH3 binding domains, domains which mediate binding to Notch or to a Notch derivative containing Notch cdc10/SW16/ankyrin ("ANK") repeats, domains which mediate binding to a second deltex protein, or any combination of the foregoing. The present invention also relates to therapeutic and diagnostic methods and compositions based on deltex proteins, nucleic acids, and antibodies. |