| abstract |
The invention includes analyses of the composition of drusen and basal laminar deposits which are implicated in age-related macular degeneration (AMD). Based on the novel observation that vitronectin is a component of drusen, the invention supplies methods of diagnosis and therapy of age-related macular degeneration. Vitronectin is implicated in the development of AMD. Also, vitronectin is identified as a component of the trabecular meshwork in patients with glaucoma. In vitro, in vivo and ex vivo methods are included. |