http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9516048-A3

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filingDate 1994-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6b6e716e1d3036d0cd6f1e0448b44dd
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publicationDate 1995-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9516048-A3
titleOfInvention Recombinant protein production in bovine adenovirus expression vector system
abstract The present invention relates novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.
priorityDate 1993-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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