abstract |
A class of substituted isoxazole and pyrazole derivatives of formula (I), or a salt thereof or a prodrug thereof, wherein the broken circle represents two non-adjacent double bonds whereby the five-membered ring containing X and Y is aromatic; one of X and Y represents nitrogen, and the other of X and Y represents oxygen or N-R5; R1 represents hydrogen, C¿1-6? alkyl or trifluoromethyl; R?2 and R3¿ independently represent hydrogen, hydrocarbon, a heterocyclic group, halogen, cyano, trifluoromethyl, nitro, -OR?a, -SRa, -SORa, -SO¿2Ra, -SO2NR?aRb, -NRaRb, -NRaCORb, -NRaCO¿2R?b, -CORa, -CO¿2Ra or -CONRaRb; R4 represents hydrocarbon or a heterocyclic group; R5 represents hydrogen or C¿1-6? alkyl; and R?a and Rb¿ independently represent hydrogen, hydrocarbon or a heterocyclic group, are ligands for dopamine receptor subtypes within the body and are therefore useful in the treatment and/or prevention of disorders of the dopamine system, in particular schizophrenia. |