| abstract |
A 2-oxoindoline derivative represented by general formula (I) and a pharmacologically acceptable salt thereof, wherein ring A represents (un)substituted benzene; R1 represents hydrogen, cycloalkyl, aryl, nitrogenous heterocycle, oxygenous heterocycle, sulfurous heterocycle, heterocycle containing nitrogen and oxygen, heterocycle containing nitrogen and sulfur, lower alkoxy, carboxy, cyano, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, oxiranyl, or 2-(lower alkylthio)-1-hydroxyethyl; R2 represents aryl, a group represented by formula (a), (un)substituted nitrogenous heteromonocycle, (un)substituted nitrogenous heterobicycle, a group represented by formula (b), (wherein n represnts 1 or 2), oxygenous heterocycle, sulfurous heterocycle, heterocyle containing nitrogen and oxygen or heterocycle containing nitrogen and sulfur; R3 represents (un)substituted lower alkyl; Q represents a single bond or lower alkylene; and Y represents a single bond, lower alkylene or lower alkinylene. |