| abstract |
The present invention relates to a novel receptor tyrosine kinase, herein referred to as tie-2, to nucleotide sequences and expression vectors encoding tie-2, and to methods of inhibiting tie-2 activity. The invention also relates to other members of the tie-2 receptor tyrosine kinase family. Genetically engineered host cells that express tie-2 may be used to evaluate and screen drugs involved in tie-2 activation and regulation. The invention relates to the use of such drugs as agonists or antagonists of tie-2 activity. |