| abstract |
A biologically active composition made up of core particles or surfaces which are coated with a layer which is designed to allow attachment of biochemically reactive pairs (BRP's) without denaturing the BRP. BRPs which may be attached include ligand-receptor pairs, enzyme-substrate pairs, drug-receptor pairs, catalyst-reactant pairs, toxin-ligand pairs, absorbant-absorbate pairs and adsorbant-adsorbate pairs. Also disclosed are biologically active compositions made up of biodegradable core particles which are coated with a layer that is designed to allow attachment of biologically active agents without denaturing them. The compositions may further include an exterior targeting membrane which provides selective targeting to specific receptors. In addition, biologically active compositions for use in gene therapy and other transfection procedures are disclosed. The compositions are composed of nanocrystalline core particles which are coated with a layer that is designed to allow attachment of transfection agents (DNA/RNA segments or antisense fragments) without denaturing them. The composition may further include an exterior targeting membrane which provides selective targeting of the transfection agents to specific cell receptors. |