Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcff13f8573db698307f919e6385d5c4 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-022 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4746 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82 |
filingDate |
1994-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa31766dacbd80e50f449105177ed716 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4761abf10d2ed7bd5ccdb23cc2aefe19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6080d307c83c07357f0a996c2fb9ab1b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ce1e98973a696ab5969caffa0a8c44f |
publicationDate |
1995-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-9511301-A1 |
titleOfInvention |
P53-mediated apoptosis |
abstract |
The invention is directed to methods of reducing the viability of a proliferating mammalian cells such as cancer cells. In one method cells deficient in p53 activity and in p53 suppressor activity of one or more p53-interacting regulatory proteins cell viability is reduced by increasing the level or activity of p53 in the cell. In another method viability of cells exhibiting p53 activity and p53 suppressor activity of one or more p53-interacting regulatory proteins is reduced by reducing the suppressor activity of the one or more p53-interacting regulatory proteins. Further, cell viability is reduced in cells deficient in p53 activity and exhibiting p53 suppressor activity of one or more p53-interacting regulatory proteins by a method that includes: (a) increasing the level or activity of p53 in the cell, and (b) reducing the suppressor activity of the one or more p53-interacting regulatory proteins. Also, included are methods of selectively reducing the viability of proliferating cancer cells compared to nonproliferating normal cells within a mixed population of cells and to methods of selectively reducing the viability of chronic granulocytic leukemia cells within a sample of proliferating bone marrow cells. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6740739-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6503502-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7033750-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6462176-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6469144-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7109179-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9722695-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9711170-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9722695-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6482803-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6511847-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7285533-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7314619-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6998117-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6998116-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6830749-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6740320-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6030945-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6342369-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6905873-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6797702-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8318689-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6805858-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6746668-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2742766-A1 |
priorityDate |
1993-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |