| abstract |
A farnesyltransferase inhibitor and an antitumor drug each containing a piperazinedione derivative represented by general formula (I) as the active ingredient, wherein R?1 and R2¿ are the same or different from each other and each represents lower alkyl, lower alkoxyalkyl, or (un)substituted aryl or aralkyl; R?3 and R4¿ are the same or different from each other and each represents mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio or aryloxycarbonylthio, or R?3 and R4¿ are combined with each other to represent a disulfide bond; and R?5 and R6¿ are the same or different from each other and each represents hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl or aralkyl. |