| abstract |
The invention provides macrolides of formula (I) wherein R1 is H, alkyl, aryl, or acyl; R2 is H, or -OR5, such that R5 is H, alkyl, aryl, or acyl; R3 is -CH2- or -CH2CH2-; and R4 is H, alkyl, acyl, or aryl; preferably wherein 'alkyl' refers to C1-6 alkyl; 'aryl' refers to an aromatic hydrocarbon radical having one or two aromatic rings; and 'acyl' is alkylcarbonyl or arylcarbonyl. Pharmaceutical compositions, pharmaceutical uses, assays, methods for producing the macrolides, and a novel producer strain are also provided. |