| abstract |
Radionuclide chelating compounds are provided for conjugation to targetting molecules such as proteins, peptides or antibodies. The resulting radiolabelled compounds are useful in diagnosis and therapy. In formula (I) R1, R2, R5 and R6 are independently selected from H; carboxyl; C1-3alkyl; and C1-3alkyl substituted with a group selected from hydroxyl, sulfhydryl, halogen, carboxyl and aminocarbonyl; R3 and R4 are independently selected from H and a sulfur protecting group; X is selected from O, the group NH2+, and the group CH¿2?; Y and Z are independently selected from the group CR1R2 and NR7; and R7 is selected from H, carboxyl, C1-3alkyl and C1-3alkyl substituted with a group selected from hydroxyl, carboxyl and halogen. |