| abstract |
The present invention is related to a method of treating migraine headaches, preferably migraines such as those caused by cortical spreading depression, with an effective amount of a low affinity NMDA receptor antagonist. Suitable low affinity NMDA receptor antagonists are benzmorphan derivatives and analogs, such as those described herein. Suitable low affinity NMDA receptor antagonists are 3-(Cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-8-yl-3-[(pyridinyl carbonyl)oxy]-3-benzocine, metazocine, normetazocine, cyclazocine, norcyclazocine, alazocine, 1-N-allylnormetazocine, and phenazocine and pharmaceutically acceptable salts thereof. |