| abstract |
A gene, NACP, is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the NACP nucleotide and polypeptide sequences. The NACP polypeptide is a precursor of NAC, a peptide associated with amyloid deposits in the brains of patients with typical neuropathological features of Alzheimer's disease (AD). Also disclosed is the amino acid sequence of NAC and of two contiguous fragments thereof, X and Y peptides. Diagnostic and therapeutic methods relating to amyloid disorders associated with NAC are also disclosed. |