| abstract |
The present invention is concerned with compounds having formula (I), the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C¿1-6?alkyl; R?2¿ is hydrogen or C¿1-6?alkyl; R?3¿ is C¿1-6?alkyl, hydroxy, cyano, halo, C1-6alkyloxy, aryloxy, arylmethoxy, C2-6alkenyl, C2-6alkynyl, C1-6alkyl-S-, C1-6alkyl(S=O)-, C1-6alkylcarbonyl; R?4¿ is hydrogen, halo, hydroxy, C¿1-6?alkyl, or C1-6alkyloxy; or R?3 and R4¿ taken together form a bivalent radical; R?5 and R6¿ each independently are hydrogen, halo, hydroxy, C¿1-6?alkyl, C1-6alkyloxy, aryloxy or arylmethoxy; R?7¿ is hydrogen; Alk1 is C¿2-5?alkanediyl; Alk?2¿ is C¿2-15?alkenediyl; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula (aa), pharmaceutical compositions, preparations and use as a medicine are described. |