| abstract |
Vascular Endothelial Growth Factor (VEGF), also known as vascular permeability factor (VPF), has been shown to play in integral role in abnormal angiogenesis associated with a variety of pathological states. This disclosure presents compounds, compositions, and methods for inhibiting such abnormal angiogenesis. In particular, this disclosure presents several antisense oligonucleotides from 19 to 21 bases long that bind to VEGF RNA and inhibit production of the expression product. These antisense oligonucleotides are useful in the treatment of pathological states in which VEGF expression plays a role. |